Two sample MR report
KANSL1-AS1_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 62 | 0.0144647 | 0.0181411 | 0.4283944 |
| Weighted median | 62 | 0.0208908 | 0.0026762 | 0.0000000 |
| Inverse variance weighted | 62 | 0.0186535 | 0.0020239 | 0.0000000 |
| Simple mode | 62 | 0.0210035 | 0.0056318 | 0.0004228 |
| Weighted mode | 62 | 0.0207535 | 0.0052366 | 0.0001965 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 24.75620 | 60 | 0.9999843 |
| Inverse variance weighted | 24.81019 | 61 | 0.9999897 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0038116 | 0.0164044 | 0.817056 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0024384 | 0 | TRUE | 2.7e-06 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
